Aims: To compare if there is an improvement in visual functions with age-related cataracts between patients\r\nreceiving customized selected aspherical intraocular lens (IOL) implants and patients randomly assigned lenses.\r\nMethods: Ninety-four patients (94 eyes) with age-related cataracts were placed in experimental group or a\r\ngroup receiving randomly assigned (RA) lenses. All patients were undergone Pentacam corneal spherical aberration\r\nmeasurement before surgery; The targeted range for residual total spherical aberration after surgery was set to 0-0.3\r\n�µm in experimental group. Patients with a corneal spherical aberration = 0.3 �µm were implanted with a zero-spherical\r\naberration advanced optics (AO) aspherical intraocular lens and patients with an aberration 0.3 �µm received a Tecnis\r\nZA9003 aspherical lens. RA patients were randomly implanted with an AO lens or a Tecnis ZA9003 lens. Three months\r\nafter surgery total spherical aberration, photopic/mesopic contrast sensitivities, photopic/mesopic with glare contrast\r\nsensitivities, and LogMAR vision were measured.\r\nResults: Statistical analysis on LogMAR vision showed no significant difference between two groups (P = 0.308).\r\nThe post-surgical total spherical aberration was 0.120 �± 0.097 �µm and 0.158 �± 0.152 �µm in the experimental and RA\r\ngroups, respectively (P = 0.08). The mesopic contrast sensitivities at spatial frequencies of 6, 12 and 18 c/d in the\r\nexperimental group were significantly higher than of the RA group (P = 0.00; P = 0.04; P = 0.01). The mesopic with\r\nglare contrast sensitivity in the RA group at a spatial frequency of 18 c/d was also significantly higher vs. the RA group\r\n(P = 0.02).\r\nConclusion: Pre-surgical corneal spherical aberration measurement in cataract patients followed by customized\r\nselection of aspherical intraocular lens implants improved mesopic contrast sensitivities and mesopic with glare contrast\r\nsensitivities at high spatial frequencies, and thus is a superior strategy compared to the random selection of aspherical\r\nintraocular lens implants.
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